Aldh1l1^tm1(cre)Pfw
Targeted Allele Detail

Summary

• Symbol: Aldh1l1^tm1(cre)Pfw
• Name: aldehyde dehydrogenase 1 family, member L1; targeted mutation 1, Paul Worley
• MGI ID: MGI:5635921
• Gene: Aldh1l1 Location: Chr6:90527751-90576153 bp, + strand Genetic Position: Chr6, 40.16 cM
• Alliance: Aldh1l1^tm1(cre)Pfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217386
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase, Reporter)
• Mutation: Insertion
• Aldh1l1^tm1(cre)Pfw expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aldh1l1 (MGI:1340024)

• Mutation details: An EGFP-cre cDNA was inserted right after the promoter. The insertion disrupts the reading frame. Western blot analysis confirmed the absence of protein in the brain. (J:217386)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1l1 (mouse) Summary of all recombinase alleles driven by Aldh1l1. Alliance mouse Aldh1l1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1l1 Mutation: 58 strains or lines available

References

• Original: J:217386 Zou Y, et al., Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J Neurosci. 2014 Nov 19;34(47):15764-78
• All: 1 reference(s)