Tek^{tm1.1(icre/Esr1*)Hrr}
Targeted Allele Detail

Summary

• Symbol: Tek^{tm1.1(icre/Esr1*)Hrr}
• Name: TEK receptor tyrosine kinase; targeted mutation 1.1, Hans-Reimer Rodewald
• MGI ID: MGI:5635996
• Synonyms: Tie2^MCM, Tie2^MCMdeltaNeo, Tie2^MeriCreMer
• Gene: Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
• Alliance: Tek^{tm1.1(icre/Esr1*)Hrr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219867
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tek^{tm1.1(icre/Esr1*)Hrr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tek (MGI:98664)

• Mutation details: The targeting cassette inserted into exon 1 upstream of the translation start site a rabbit HBB2 splice donor, intron and splice acceptor; an inducible improved cre fused to two modified Esr1 binding domains (icre/Esr1*); and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:219867)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tek Mutation: 92 strains or lines available

References

• Original: J:219867 Busch K, et al., Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Nature. 2015 Feb 26;518(7540):542-6
• All: 6 reference(s)