Tg(Th-ALK*F1174L)2Loch
Transgene Detail

Summary

• Symbol: Tg(Th-ALK*F1174L)2Loch
• Name: transgene insertion 2, Louis Chesler
• MGI ID: MGI:5636485
• Transgene: Tg(Th-ALK*F1174L)2Loch Location: unknown
• Alliance: Tg(Th-ALK*F1174L)2Loch page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-ALK*F1174L)2Loch expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALK (238)

  Alk	(MGI:103305)

• Tg(Th-ALK*F1174L)2Loch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: The human ALK cDNA with the F1174L mutation is under the control of the rat tyrosine hydroxylase promoter, which drives expression in committed sympathetic precursor cells of the neural crest. Four lines were established; 1, 2, 3, and 4. Line 2 is entered as a representative line. (J:191012)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:191012 Berry T, et al., The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma. Cancer Cell. 2012 Jul 10;22(1):117-30
• All: 6 reference(s)