Grxcr2^tm1.1Dck
Targeted Allele Detail

Summary

• Symbol: Grxcr2^tm1.1Dck
• Name: glutaredoxin, cysteine rich 2; targeted mutation 1.1, David Kohrman
• MGI ID: MGI:5636505
• Synonyms: Grxcr2^delta
• Gene: Grxcr2 Location: Chr18:42118388-42132114 bp, - strand Genetic Position: Chr18, 22.14 cM
• Alliance: Grxcr2^tm1.1Dck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265041
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1. Immunoreactivity confirmed the absence of protein expression in cochlear stereocilia bundles. (J:265041)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grxcr2 Mutation: 13 strains or lines available

References

• Original: J:265041 Avenarius MR, et al., Grxcr2 is required for stereocilia morphogenesis in the cochlea. PLoS One. 2018;13(8):e0201713
• All: 2 reference(s)