Wdr1^tm1.1Zzy
Targeted Allele Detail

Summary

• Symbol: Wdr1^tm1.1Zzy
• Name: WD repeat domain 1; targeted mutation 1.1, Zhongzhou Yang
• MGI ID: MGI:5636587
• Synonyms: Wdr1^f
• Gene: Wdr1 Location: Chr5:38684149-38720265 bp, - strand Genetic Position: Chr5, 20.63 cM
• Alliance: Wdr1^tm1.1Zzy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211364
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:211364)

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr1 Mutation: 41 strains or lines available

References

• Original: J:211364 Yuan B, et al., A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice. Am J Pathol. 2014 Jul;184(7):1967-80
• All: 3 reference(s)