Nipbl^tm1.2Hpt
Targeted Allele Detail

Summary

• Symbol: Nipbl^tm1.2Hpt
• Name: NIPBL cohesin loading factor; targeted mutation 1.2, Heiko Peters
• MGI ID: MGI:5636687
• Synonyms: Nipbl^-, Nipbl^deltaE2
• Gene: Nipbl Location: Chr15:8320101-8473947 bp, - strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Nipbl^tm1.2Hpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213338
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a second 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:213338)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nipbl Mutation: 124 strains or lines available

References

• Original: J:213338 Smith TG, et al., Neural crest cell-specific inactivation of Nipbl or Mau2 during mouse development results in a late onset of craniofacial defects. Genesis. 2014 Jul;52(7):687-94
• All: 3 reference(s)