Heal15^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Heal15^CAST/EiJ
• Name: wound healing/regeneration 15; CAST/EiJ
• MGI ID: MGI:5636701
• QTL: Heal15 Location: Chr2:4989519-4989642 bp Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:91685

Linkage analysis was performed on 301 (MRL/MpJ x CAST/EiJ)F2 intercross animals to identify QTLs associated with wound healing. Ear hole punch was inflicted on 6 week old animals and wound healing was assessed via ear hole closure. Parental strain MRL/MpJ can fully heal ear hole wounds within 30 days whereas parental strain CAST/Ei cannot. In general female animals are better healers than males (50% faster healing.) Genome scan was performed at an average resolution of 9.4 cM.

A suggestive QTL, Heal15, was identified on mouse Chromosome 2 mapping between 0-5cM peaking at marker D2Mit354. It was seen only in heterozygous mice at this locus.

References

• Original: J:91685 Heber-Katz E, et al., Regeneration in MRL mice: further genetic loci controlling the ear hole closure trait using MRL and M.m. Castaneus mice. Wound Repair Regen. 2004 May-Jun;12(3):384-92
• All: 1 reference(s)