Gt(ROSA)26Sor^tm1(GRN)Pvd
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(GRN)Pvd
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philip Van Damme
• MGI ID: MGI:5636723
• Synonyms: hPGRN
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(GRN)Pvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211734
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(GRN)Pvd expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GRN (2896)

  Grn	(MGI:95832)

• Mutation details: A floxed neo-stop cassette, a human GRN cDNA and IRES-GFP were inserted in the locus via homologous recombination. (J:211734)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:211734 Herdewyn S, et al., Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats. Neurobiol Aging. 2013 Oct;34(10):2302-3
• All: 2 reference(s)