Oprk1^tm1.1Waca
Targeted Allele Detail

Summary

• Symbol: Oprk1^tm1.1Waca
• Name: opioid receptor, kappa 1; targeted mutation 1.1, William A Carlezon Jr
• MGI ID: MGI:5636741
• Synonyms: KOR^lox
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^tm1.1Waca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211750
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:211750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 30 strains or lines available

References

• Original: J:211750 Van't Veer A, et al., Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology. 2013 Jul;38(8):1585-97
• All: 3 reference(s)