Srpk1tm1.1Xdfu
Targeted Allele Detail
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Symbol: |
Srpk1tm1.1Xdfu |
Name: |
serine/arginine-rich protein specific kinase 1; targeted mutation 1.1, Xiang-Dong Fu |
MGI ID: |
MGI:5636749 |
Gene: |
Srpk1 Location: Chr17:28806622-28841683 bp, - strand Genetic Position: Chr17, 14.78 cM
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Alliance: |
Srpk1tm1.1Xdfu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:213142
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance selection cassette with a 5' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts.
(J:213142)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Srpk1 Mutation: |
48 strains or lines available
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Original: |
J:213142 Wang P, et al., Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 8;54(3):378-91 |
All: |
1 reference(s) |
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