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Srpk1tm1.1Xdfu
Targeted Allele Detail
Summary
Symbol: Srpk1tm1.1Xdfu
Name: serine/arginine-rich protein specific kinase 1; targeted mutation 1.1, Xiang-Dong Fu
MGI ID: MGI:5636749
Gene: Srpk1  Location: Chr17:28806622-28841683 bp, - strand  Genetic Position: Chr17, 14.78 cM
Alliance: Srpk1tm1.1Xdfu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213142
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance selection cassette with a 5' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:213142)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srpk1 Mutation:  48 strains or lines available
References
Original:  J:213142 Wang P, et al., Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 8;54(3):378-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory