Skts14^NIH/Ola
QTL Variant Detail

Summary

• QTL variant: Skts14^NIH/Ola
• Name: skin tumor susceptibility 14; NIH/Ola
• MGI ID: MGI:5636821
• QTL: Skts14 Location: Chr7:25386427-25404502 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: NIH/Ola

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:110209

Using a panel of markers from 306 (NIH/Ola x outbred Mus spretus)F1 x NIH/Ola (NSP) backcross animals, to identify skin tumor susceptibility QTL, two linkage peaks were indicated.

The proximal locus, Skts14, mapped to app 14.0Mb on Chromosome 7, peaking at Tgfb1 a very strong candidate gene for influencing cancer risk.

Previous studies [J:27733] demonstrated the existance of a skin tumor susceptibility locus, Skts1, on proximal chromosome 7 that controls papilloma development. The current study using the same cross, confimed this QTL.

References

• Original: J:110209 Mao JH, et al., Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8125-30
• All: 1 reference(s)