Nrxn1^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Nrxn1^{tm1b(KOMP)Wtsi}
• Name: neurexin I; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5636923
• Gene: Nrxn1 Location: Chr17:90341059-91400499 bp, - strand Genetic Position: Chr17, 59.73 cM
• Alliance: Nrxn1^{tm1b(KOMP)Wtsi} page
• IMPC: Nrxn1 gene page

Mutation origin

• Mutant Cell Line: EPD0796_5_E08
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Nrxn1^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Nrxn1^tm1b(KOMP)Wtsi/Nrxn1^tm1b(KOMP)Wtsi	C57BL/6N-Nrxn1^tm1b(KOMP)Wtsi/H	EPD0796_5_E08
ht2	Nrxn1^tm1b(KOMP)Wtsi/Nrxn1^+	C57BL/6N-Nrxn1^tm1b(KOMP)Wtsi/H	EPD0796_5_E08

Phenotypes:

Affected Systems	hm1		ht2
show or hide all annotated terms Sex:
Source:	IMPC - HAR	IMPC - HAR	IMPC - HAR	IMPC - HAR
adipose tissue		√
decreased total body fat amount		√
behavior/neurological	√	√	√	√
tremors	√	√	√	√
decreased grip strength	√	√
growth/size/body				√
increased lean body mass				√
hematopoietic system		√		√
increased red blood cell distribution width		√
increased neutrophil cell number		√		√
decreased lymphocyte cell number		√
increased monocyte cell number		√
homeostasis/metabolism	√	√		√
decreased fasting circulating glucose level	√
decreased circulating cholesterol level		√
decreased circulating HDL cholesterol level		√
decreased circulating alkaline phosphatase level	√
increased circulating amylase level				√
increased circulating aspartate transaminase level	√	√
decreased circulating serum albumin level		√
decreased circulating total protein level		√
impaired glucose tolerance	√	√
immune system		√		√
increased neutrophil cell number		√		√
decreased lymphocyte cell number		√
increased monocyte cell number		√
respiratory system	√
decreased pulmonary respiratory rate	√
skeleton	√
abnormal bone structure	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrxn1 Mutation: 98 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 5 reference(s)