Cep15^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cep15^{tm1b(KOMP)Wtsi}
• Name: centrosomal protein 15; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5637049
• Gene: Cep15 Location: Chr14:10166532-10185590 bp, - strand Genetic Position: Chr14, 6.34 cM
• Alliance: Cep15^{tm1b(KOMP)Wtsi} page
• IMPC: Cep15 gene page

Mutation origin

• Mutant Cell Line: EPD0889_1_C08
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental 3830406C13Rik^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Cep15^tm1b(KOMP)Wtsi/Cep15^tm1b(KOMP)Wtsi	C57BL/6N-Cep15^tm1b(KOMP)Wtsi/Wtsi	EPD0889_1_C08

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
Source:	IMPC - WTSI
hematopoietic system	√
increased red blood cell distribution width	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cep15 Mutation: 10 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 4 reference(s)