Camta1^tm1.2Eno
Targeted Allele Detail

Summary

• Symbol: Camta1^tm1.2Eno
• Name: calmodulin binding transcription activator 1; targeted mutation 1.2, Eric N Olson
• MGI ID: MGI:5637358
• Synonyms: CAMTA1^-
• Gene: Camta1 Location: Chr4:151143980-151946225 bp, - strand Genetic Position: Chr4, 81.53 cM
• Alliance: Camta1^tm1.2Eno page

Runting and abnormal posture of Camta1^tm1.2Eno/Camta1^tm1.2Eno mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212232
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 9 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 9 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exon 9. This results in a frame-shift mutation after amino acid 284 that eliminates the majority of functional domains, creating a loss-of-function allele. The CG-1 domain contained within the residual portion of the mutated gene is not expected to function as a dominant-negative mutant. (J:212232)

Generation of the Camta1^tm1.1Eno and Camta1^tm1.2Eno alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camta1 Mutation: 82 strains or lines available

References

• Original: J:212232 Long C, et al., Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11521-6
• All: 1 reference(s)