Vwftm3.1(VWF)Diac
Targeted Allele Detail
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Symbol: |
Vwftm3.1(VWF)Diac |
Name: |
Von Willebrand factor; targeted mutation 3.1, Thomas G Diacovo |
MGI ID: |
MGI:5637368 |
Synonyms: |
VWFHA1 |
Gene: |
Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
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Alliance: |
Vwftm3.1(VWF)Diac page
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Germline Transmission: |
Earliest citation of germline transmission:
J:220792
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Vwftm3.1(VWF)Diac expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
VWF (7450) |
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Mutation details: The majority of murine exon 28 was replaced with the human VWF A1 domain (amino acids 1240P through 1481G). In addition a floxed pGK-Neo cassette was inserted downstream of exon 28 which was removed via cre-mediated excision.
(J:220792)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Vwf Mutation: |
140 strains or lines available
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Original: |
J:220792 Chen J, et al., Exploiting the kinetic interplay between GPIbalpha-VWF binding interfaces to regulate hemostasis and thrombosis. Blood. 2014 Dec 11;124(25):3799-807 |
All: |
1 reference(s) |
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