Nfatc1^{tm1.1(cre/ERT2)Bzsh}
Targeted Allele Detail

Summary

• Symbol: Nfatc1^{tm1.1(cre/ERT2)Bzsh}
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou
• MGI ID: MGI:5637438
• Synonyms: Nfatc1-CreER
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^{tm1.1(cre/ERT2)Bzsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212075
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Nfatc1^{tm1.1(cre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nfatc1 (MGI:102469)

• Mutation details: The coding sequence in exon 1 from the translation start site was replaced by an inducible cre recombinase gene (cre/ERT2). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the recombinase. Immunohistochemistry confirmed expression in the atrial and ventricular endocardium, but not sinus venosus, at E8.5 and E9.5. (J:212075)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nfatc1 (mouse) Summary of all recombinase alleles driven by Nfatc1. Comparative matrix view of recombinase activities Alliance mouse Nfatc1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 49 strains or lines available

References

• Original: J:212075 Tian X, et al., Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 4;345(6192):90-4
• All: 9 reference(s)