Tg(MMTV-Espl1)1Pati
Transgene Detail

Summary

• Symbol: Tg(MMTV-Espl1)1Pati
• Name: transgene insertion 1, Debananda Pati
• MGI ID: MGI:5637741
• Transgene: Tg(MMTV-Espl1)1Pati Location: unknown
• Alliance: Tg(MMTV-Espl1)1Pati page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Espl1)1Pati expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Espl1 (MGI:2146156)

• Mutation details: The mouse mammary tumor virus long terminal repeats were used to drive mammary epithelium-specific expression of the full-length mouse Espl1 cDNA. Western blot and immunofluorescence confirmed expression in mammary glands of adult females at day 5 of lactation. Four lines were generated but two (Tg1 and Tg2) were used for studies. (J:216267)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:216267 Mukherjee M, et al., MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERalpha)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27;33(48):5511-22
• All: 1 reference(s)