Albq10^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Albq10^MRL/MpJ
• Name: albuminuria QTL 10; MRL/MpJ
• MGI ID: MGI:5637832
• QTL: Albq10 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:175511

Linkage analysis was performed on 371 male (MRL/MpJ x SM/J)F2 intercross animals using 258 SNP markers to identify QTL associated with increased urinary albumin-to-creatinine ratio (ACR). Parental strain SM/J exhibits higher ACR values when compared to MRL/MpJ.

QTL Albq10 maps to 35.3 - 124.2 Mb on Chromosome 1 with a peak LOD score of 4.1 at 46 cM in linkage with urinary ACR. SM/J alleles confer increased susceptibility to increased ACR values.

References

• Original: J:175511 Hageman RS, et al., Uncovering genes and regulatory pathways related to urinary albumin excretion. J Am Soc Nephrol. 2011 Jan;22(1):73-81
• All: 1 reference(s)