Sox7^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Sox7^tm1.1Nat
• Name: SRY (sex determining region Y)-box 7; targeted mutation 1.1, Jeremy Nathans
• MGI ID: MGI:5638074
• Synonyms: Sox7^fl, Sox7^flox
• Gene: Sox7 Location: Chr14:64181155-64188181 bp, + strand Genetic Position: Chr14, 33.34 cM, cytoband C3
• Alliance: Sox7^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264733
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: LoxP sites are inserted (1) within the first exon 5' of the initiator methionine codon, and (2) 3' of an SV40 polyadenylation signal that is inserted immediately 3' of the 3' UTR. Inserted downstream of the 3' loxP site are the coding region for CFP with a 3' HA tag, an FRT site, a phosphoglycerate kinase (PGK)-Neo cassette, a third loxP site and an FRT site. (J:264733)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox7 Mutation: 21 strains or lines available

References

• Original: J:264733 Zhou Y, et al., Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS One. 2015;10(12):e0143650
• All: 4 reference(s)