Sox17^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Sox17^tm1.1Nat
• Name: SRY (sex determining region Y)-box 17; targeted mutation 1.1, Jeremy Nathans
• MGI ID: MGI:5638079
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264733
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: LoxP sites are inserted within the first coding exon 5' of the initiator methionine codon, and 3' of an SV40 polyadenylation signal that is inserted immediately 3' of the 3' UTR. The following is downstream of the 3' loxP site: the coding region for human placental alkaline phosphatase (AP), and an FRT-flanked phosphoglycerate kinase (PGK)-Neo cassette (FNF). (J:264733)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

References

• Original: J:264733 Zhou Y, et al., Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS One. 2015;10(12):e0143650
• All: 3 reference(s)