Sohlh2^tm1Fkh
Targeted Allele Detail

Summary

• Symbol: Sohlh2^tm1Fkh
• Name: spermatogenesis and oogenesis specific basic helix-loop-helix 2; targeted mutation 1, Franklin Kent Hamra
• MGI ID: MGI:5638449
• Gene: Sohlh2 Location: Chr3:55089465-55117378 bp, + strand Genetic Position: Chr3, 26.53 cM
• Alliance: Sohlh2^tm1Fkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220953
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 7 through 9. (J:220953)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sohlh2 Mutation: 27 strains or lines available

References

• Original: J:220953 Hao J, et al., Sohlh2 knockout mice are male-sterile because of degeneration of differentiating type A spermatogonia. Stem Cells. 2008 Jun;26(6):1587-97
• All: 1 reference(s)