Neurog2^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Neurog2^tm1.1Meg
• Name: neurogenin 2; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:5638453
• Synonyms: Ngn2^S231A&S234A
• Gene: Neurog2 Location: Chr3:127426784-127429280 bp, + strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Neurog2^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221029
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution resulted in the amino acid substitution of serine with alanine at positions 231 and 234 (p.S231A, p.S234A), abolishing phosphorylation potential at those residues. Serine codon 218 was changed from TCA to AGC as a silent mutation to create a diagnostic SacI restriction site. Cre-mediated recombination removed a loxP site flanked neomycin resistance gene cassette that was inserted downstream of the gene. (J:221029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurog2 Mutation: 18 strains or lines available

References

• Original: J:221029 Ma YC, et al., Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron. 2008 Apr 10;58(1):65-77
• All: 1 reference(s)