Camk2b^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Camk2b^tm1.1Ics
• Name: calcium/calmodulin-dependent protein kinase II, beta; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5638541
• Synonyms: CaMKIIbeta KO
• Gene: Camk2b Location: Chr11:5919644-6016362 bp, - strand Genetic Position: Chr11, 3.89 cM
• Alliance: Camk2b^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219040
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 7 and 8 were floxed by two LoxP sequences, followed by a frt-neo-frt cassette in intron 8. Floxed exons 7 and 8 and the neo cassette were then removed. Western analysis confirmed the absence of expression. (J:219040)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2b Mutation: 92 strains or lines available

References

• Original: J:219040 Bachstetter AD, et al., Generation and behavior characterization of CaMKIIbeta knockout mice. PLoS One. 2014;9(8):e105191
• All: 1 reference(s)