Ruvbl1^tm1.1Oxbk
Targeted Allele Detail

Summary

• Symbol: Ruvbl1^tm1.1Oxbk
• Name: RuvB-like AAA ATPase 1; targeted mutation 1.1, Oxana Bereshchenko
• MGI ID: MGI:5638544
• Synonyms: Ruvbl1^fl
• Gene: Ruvbl1 Location: Chr6:88442391-88474548 bp, + strand Genetic Position: Chr6, 39.51 cM
• Alliance: Ruvbl1^tm1.1Oxbk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220926
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exons 1 and 2 floxed. (J:220926)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ruvbl1 Mutation: 52 strains or lines available

References

• Original: J:220926 Bereshchenko O, et al., Pontin is essential for murine hematopoietic stem cell survival. Haematologica. 2012 Sep;97(9):1291-4
• All: 2 reference(s)