Rraga^tm2.1Dmsa
Targeted Allele Detail

Summary

• Symbol: Rraga^tm2.1Dmsa
• Name: Ras-related GTP binding A; targeted mutation 2.1, David Sabatini
• MGI ID: MGI:5638549
• Synonyms: RagA^delta
• Gene: Rraga Location: Chr4:86493910-86495522 bp, + strand Genetic Position: Chr4, 40.69 cM
• Alliance: Rraga^tm2.1Dmsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213516
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 300 bp upstream of the coding region and an FRT flanked neo cassette and loxP site were inserted 500 bp downstream of the coding region via homologous recombination. Cre mediated recombination removed the coding region and the neo cassette. (J:213516)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rraga Mutation: 17 strains or lines available

References

• Original: J:213516 Efeyan A, et al., RagA, but not RagB, is essential for embryonic development and adult mice. Dev Cell. 2014 May 12;29(3):321-9
• All: 1 reference(s)