Cyp2c23^tm1.1Jhc
Targeted Allele Detail

Summary

• Symbol: Cyp2c23^tm1.1Jhc
• Name: cytochrome P450, family 2, subfamily c, polypeptide 23; targeted mutation 1.1, Jorge H Capdevila
• MGI ID: MGI:5638557
• Synonyms: Cyp2c44^loxP
• Gene: Cyp2c23 Location: Chr19:43993461-44017647 bp, - strand Genetic Position: Chr19, 36.69 cM
• Alliance: Cyp2c23^tm1.1Jhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213555
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 9 and floxed neo cassette was inserted downstream of exon 9 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 9 floxed. (J:213555)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2c23 Mutation: 28 strains or lines available

References

• Original: J:213555 Wang WH, et al., Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F453-60
• All: 3 reference(s)