Tgfbi^tm1Jwu
Targeted Allele Detail

Summary

• Symbol: Tgfbi^tm1Jwu
• Name: transforming growth factor, beta induced; targeted mutation 1, Jiangping Wu
• MGI ID: MGI:5638662
• Gene: Tgfbi Location: Chr13:56757399-56787172 bp, + strand Genetic Position: Chr13, 30.09 cM, cytoband B-C1
• Alliance: Tgfbi^tm1Jwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213611
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 - 11 were replaced with a neo cassette via homologous recombination. RT-QPCR and ELISA analysis confirmed the absence of expression in tissues from homozygous mutant mice. (J:213611)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbi Mutation: 34 strains or lines available

References

• Original: J:213611 Han B, et al., TGFBI (betaIG-H3) is a diabetes-risk gene based on mouse and human genetic studies. Hum Mol Genet. 2014 Sep 1;23(17):4597-611
• All: 1 reference(s)