Mex3b^tm1.2Mbld
Targeted Allele Detail

Summary

• Symbol: Mex3b^tm1.2Mbld
• Name: mex3 RNA binding family member B; targeted mutation 1.2, Marc Billaud
• MGI ID: MGI:5638674
• Synonyms: Mex3b^-
• Gene: Mex3b Location: Chr7:82516541-82520723 bp, + strand Genetic Position: Chr7, 47.35 cM
• Alliance: Mex3b^tm1.2Mbld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was floxed and a floxed neo cassette was inserted via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. Molecular analyses confirmed the absence of mRNA and protein in both mouse embryonic fibroblasts (MEFs) and testis extracts from homozygous mutant mice. (J:213588)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mex3b Mutation: 19 strains or lines available

References

• Original: J:213588 Le Borgne M, et al., The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. Development. 2014 May;141(10):2096-107
• All: 1 reference(s)