Lmnb1^{tm3(Lmnb2)Sgy}
Targeted Allele Detail

Summary

• Symbol: Lmnb1^{tm3(Lmnb2)Sgy}
• Name: lamin B1; targeted mutation 3, Stephen G Young
• MGI ID: MGI:5638709
• Synonyms: Lmnb1^B2
• Gene: Lmnb1 Location: Chr18:56840885-56886496 bp, + strand Genetic Position: Chr18, 30.84 cM
• Alliance: Lmnb1^{tm3(Lmnb2)Sgy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220914
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Lmnb1^{tm3(Lmnb2)Sgy} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lmnb2 (MGI:96796)

• Mutation details: The coding sequence in exon 1 was replaced with the mouse cDNA for Lmnb2 with two neutral restriction site changed and a floxed neomycin resistance cassette. (J:220914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmnb1 Mutation: 39 strains or lines available

References

• Original: J:220914 Lee JM, et al., Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May;25(10):1666-75
• All: 1 reference(s)