Nmnat3^Gt(3020)Tgen
Gene trapped Allele Detail

Summary

• Symbol: Nmnat3^Gt(3020)Tgen
• Name: nicotinamide nucleotide adenylyltransferase 3; gene trap 3020, TransGenic
• MGI ID: MGI:5638788
• Synonyms: Nmnat3^gt
• Gene: Nmnat3 Location: Chr9:98169488-98302491 bp, + strand Genetic Position: Chr9, 51.35 cM, cytoband E4
• Alliance: Nmnat3^Gt(3020)Tgen page

Mutation origin

• Mutant Cell Line: 3020
• Germline Transmission: Earliest citation of germline transmission: J:214107
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pU-17 Vector Type: gene trap
• Mutation details: The beta-geo containing gene trap was inserted into intron 1. Western blot analysis confirmed the absence of protein expression in red blood cells and skeletal muscle. (J:214107)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmnat3 Mutation: 17 strains or lines available

References

• Original: J:214107 Hikosaka K, et al., Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes. J Biol Chem. 2014 May 23;289(21):14796-811
• All: 4 reference(s)