Bap1^em1Test
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bap1^em1Test
• Name: Brca1 associated protein 1; endonuclease-mediated mutation 1, Joseph R Testa
• MGI ID: MGI:5638884
• Gene: Bap1 Location: Chr14:30973407-30981901 bp, + strand Genetic Position: Chr14, 19.09 cM
• Alliance: Bap1^em1Test page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Zinc finger nuclease mediated targeted mutation deleted exons 6 and 7. (J:213725)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bap1^em1Test

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bap1 Mutation: 38 strains or lines available

References

• Original: J:213725 Xu J, et al., Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma. Cancer Res. 2014 Aug 15;74(16):4388-97
• All: 2 reference(s)