Gt(ROSA)26Sor^{tm2(CAG-rtTA3,-mKate2)Slowe}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-rtTA3,-mKate2)Slowe}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Scott Lowe
• MGI ID: MGI:5638918
• Synonyms: R26Sor^{tm2(CAGs-LSL-RIK)Slo}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-rtTA3,-mKate2)Slowe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215194
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter, Transactivator)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a CAG promoter, floxed stop cassette, reverse tetracycline transactivator 3 (rtTA3), IRES and a far red reporter gene (mKate2). (J:215194)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1040 strains or lines available

Notes

ES cell line = C10, not C2 (Jaenisch) as reported by original reference. C10 ES cells carry Col1a1.

References

• Original: J:215194 Dow LE, et al., Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice. PLoS One. 2014;9(4):e95236
• All: 7 reference(s)