Casz1^tm1.1Flc
Targeted Allele Detail

Summary

• Symbol: Casz1^tm1.1Flc
• Name: castor zinc finger 1; targeted mutation 1.1, Frank Conlon
• MGI ID: MGI:5638931
• Synonyms: Casz1^f, Casz1^flox
• Gene: Casz1 Location: Chr4:148888886-149039346 bp, + strand Genetic Position: Chr4, 78.87 cM
• Alliance: Casz1^tm1.1Flc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221324
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. (J:221324)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casz1 Mutation: 345 strains or lines available

References

• Original: J:221324 Dorr KM, et al., Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development. Development. 2015 Jun 1;142(11):2037-47
• All: 2 reference(s)