Nfkb2^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb2^m2Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 2, Bruce Beutler
• MGI ID: MGI:5640748
• Synonyms: pale_fire
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is an A to T transversion at base pair 46,311,626 (v38) on chromosome 19, or base pair 8,015 in the GenBank genomic region NC_000085. The mutation corresponds to residue 2,821 in the mRNA sequence NM_019408 (variant 1) within exon 21 of 22 total exons, to residue 2,670 in the mRNA sequence NM_001177369 (variant 2) within exon 22 of 23 total exons, and residue 2,586 in the mRNA sequence NM_001177370 (variant 3) within exon 21 of 22 total exons. The mutation results in a methionine (M) to leucine (L) substitution at position 838 (M838L) in all isoforms of the protein. (J:221493)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:221493 Murray AR, et al., Mutagenetix entry for pale_fire. MGI Direct Data Submission. 2015
• All: 1 reference(s)