Cd8a^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cd8a^m1Btlr
• Name: CD8 subunit alpha; mutation 1, Bruce Beutler
• MGI ID: MGI:5640751
• Synonyms: alfalfa
• Gene: Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
• Alliance: Cd8a^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T to A transversion at base pair 71,373,728 on chromosome 6 (GRCm38), corresponding to base pair 20,957 of the genomic DNA sequence (NC_000072.6). The mutation is positioned in exon 2 out of 6 exons (variant 1) or 5 exons (variant 2). The mutation affects nucleotide 302 of Cd8a mRNA variants 1 (NM_001081110.2) and 2 (NM_009857.1). The mutation results in a valine (V) to aspartic acid (D) substitution at position 59 (V59D) of both variants. (J:221492)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd8a Mutation: 36 strains or lines available

References

• Original: J:221492 Zeng M, et al., Mutagenetix entry for alfalfa. MGI Direct Data Submission. 2015
• All: 1 reference(s)