Rab27a^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rab27a^m2Btlr
• Name: RAB27A, member RAS oncogene family; mutation 2, Bruce Beutler
• MGI ID: MGI:5640752
• Synonyms: geodude
• Gene: Rab27a Location: Chr9:72952136-73004911 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Rab27a^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T to C transition at base pair 73,084,981 (v38) on chromosome 9, or base pair 40,172 in the GenBank genomic region NC_000075. The mutation corresponds to residue 663 in the mRNA sequence NM_001301230 (isoform 1) within exon 5 of 7 total exons, residue 514 in the mRNA sequence NM_023635 (isoform 2) within exon 4 of 6 total exons, and residue 556 in the mRNA sequence NM_001301232 (isoform 3) within exon 4 of 6 total exons. The mutation results in an leucine (L) to proline (P) substitution at position 97 (L97P) in all of the isoforms. (J:221491)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab27a Mutation: 146 strains or lines available

References

• Original: J:221491 Reyna C, et al., Mutagenetix entry for geodude. MGI Direct Data Submission. 2015
• All: 1 reference(s)