Gck^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Gck^M1Btlr
• Name: glucokinase; mutation 1, Bruce Beutler
• MGI ID: MGI:5640861
• Synonyms: Grahamcracker
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T to A transversion at base pair 5,902,165 (v38) on chromosome 11, or base pair 47,917 in the GenBank genomic region NC_000077. The mutation corresponds to residue 1,655 in the mRNA sequence NM_010292 (variant 1) within exon 9 of 10 total exons and to residue 1,297 in the mRNA sequence NM_001287386 (variant 2) within exon 9 of 10 total exons. The mutation results in an asparagine (N) to lysine (K) substitution at position 391 (N391K). (J:221479)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 63 strains or lines available

References

• Original: J:221479 Chen Z, et al., Mutagenetix entry for Grahamcracker. MGI Direct Data Submission. 2015
• All: 1 reference(s)