Tg(MYOC*Y437H)#Sit
Transgene Detail

Summary

• Symbol: Tg(MYOC*Y437H)#Sit
• Name: transgene insertion, Stanilsav I Tomarev
• MGI ID: MGI:5641919
• Transgene: Tg(MYOC*Y437H)#Sit Location: unknown
• Alliance: Tg(MYOC*Y437H)#Sit page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MYOC*Y437H)#Sit expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYOC (4653)

  Myoc	(MGI:1202864)

• Mutation details: This transgene consists of the BAC DNA RP11-23L17 containing the full-length human MYOC with a Tyr437His point mutation (T to C in codon 437), as well as approximately 89 kb and 51 kb of the 5'-flanking and 3'-flanking sequences, respectively. Four lines were developed, however only one line was used for analysis. The pound symbol (#) is used when line is not specified. (J:135177)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:135177 Zhou Y, et al., Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma. Invest Ophthalmol Vis Sci. 2008 May;49(5):1932-9
• All: 3 reference(s)