Eae47^RIIIS/J
QTL Variant Detail

Summary

• QTL variant: Eae47^RIIIS/J
• Name: experimental allergic encephalomyelitis susceptibility 47; RIIIS/J
• MGI ID: MGI:5642230
• QTL: Eae47 Location: unknown Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: RIIIS/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

A locus on mouse Chromosome 18 near D18Mit4 (57 cM) showed suggestive linkage to incidence of remitting EAE disease in male animals (LRS=10.7). This locus is thought to be the previously identified QTL Eae18.

6.30.2015 Curators Note: Because Eae18 was originally mapped in J:29171 in 1995 using (ABH x NOD)F1 x NOD backcross mice, which differ from the mice used in this cross, we consider the current study a separate mapping experiment and have named this QTL Eae47.

References

• Original: J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• All: 1 reference(s)