Trmq7^RIIIS/J
QTL Variant Detail

Summary

• QTL variant: Trmq7^RIIIS/J
• Name: T cell ratio modifier QTL 7; RIIIS/J
• MGI ID: MGI:5642277
• QTL: Trmq7 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: RIIIS/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

A locus on central mouse Chromosome 2 showed linkage to percentage of CD4+ T cells in the spleen between markers D2Mit75 and D2Mit17 (LRS=20.3-22.3). This locus is near a previously identified QTL named Trmq2 (52 cM) and may be the same QTL.

07.01.2015 Curators Note: Because Trmq2 was originally mapped in J:77603 in 2002 using (C57BL/6J x DBA/2J)F1 x DBA/2J backcross mice, which differ from the mice used here, we consider the current study a separate mapping experiment and have named this QTL Trmq7 .

References

• Original: J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• All: 1 reference(s)