Fgd5^tm1Djr
Targeted Allele Detail

Summary

• Symbol: Fgd5^tm1Djr
• Name: FYVE, RhoGEF and PH domain containing 5; targeted mutation 1, Derrick Rossi
• MGI ID: MGI:5642321
• Synonyms: Fgd5^mCherry
• Gene: Fgd5 Location: Chr6:91955859-92052985 bp, + strand Genetic Position: Chr6, 41.0 cM
• Alliance: Fgd5^tm1Djr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214520
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector consists of an mCherry cassette followed by an FRT-flanked neomycin cassette inserted in frame into exon 1. mCherry expression is almost exclusively specific to bone marrow hematopoietic stem cells, with some low level of expression detected in bone marrow multipotent progenitor cells. (J:214520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgd5 Mutation: 57 strains or lines available

References

• Original: J:214520 Gazit R, et al., Fgd5 identifies hematopoietic stem cells in the murine bone marrow. J Exp Med. 2014 Jun 30;211(7):1315-31
• All: 1 reference(s)