Fgd5^tm2Djr
Targeted Allele Detail

Summary

• Symbol: Fgd5^tm2Djr
• Name: FYVE, RhoGEF and PH domain containing 5; targeted mutation 2, Derrick Rossi
• MGI ID: MGI:5642323
• Synonyms: Fgd5^ZsGr*ZsGr
• Gene: Fgd5 Location: Chr6:91955859-92052985 bp, + strand Genetic Position: Chr6, 41.0 cM
• Alliance: Fgd5^tm2Djr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214520
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector consists of tandem ZsGreen cassettes separated by a 2A peptide cassette followed by a FRT-flanked neomycin cassette inserted in frame into exon 1. ZsGreen expression is detected in all bone marrow blood vessels in adult mice by laser-scanning cytometry. (J:214520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgd5 Mutation: 57 strains or lines available

References

• Original: J:214520 Gazit R, et al., Fgd5 identifies hematopoietic stem cells in the murine bone marrow. J Exp Med. 2014 Jun 30;211(7):1315-31
• All: 2 reference(s)