Fgd5^{tm3(cre/ERT2)Djr}
Targeted Allele Detail

Summary

• Symbol: Fgd5^{tm3(cre/ERT2)Djr}
• Name: FYVE, RhoGEF and PH domain containing 5; targeted mutation 3, Derrick Rossi
• MGI ID: MGI:5642327
• Synonyms: Fgd5^ZsGr*CreERT2
• Gene: Fgd5 Location: Chr6:91955859-92052985 bp, + strand Genetic Position: Chr6, 41.0 cM
• Alliance: Fgd5^{tm3(cre/ERT2)Djr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214520
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Fgd5^{tm3(cre/ERT2)Djr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fgd5 (MGI:2443369)

• Mutation details: The targeting vector consists of ZsGreen and creERT2 cassettes separated by a 2A peptide cassette and followed by an FRT-flanked neomycin cassette inserted in frame into exon 1. (J:214520)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fgd5 (mouse) Summary of all recombinase alleles driven by Fgd5. Alliance mouse Fgd5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgd5 Mutation: 57 strains or lines available

References

• Original: J:214520 Gazit R, et al., Fgd5 identifies hematopoietic stem cells in the murine bone marrow. J Exp Med. 2014 Jun 30;211(7):1315-31
• All: 12 reference(s)