Atp13a2^tm1.2Wtd
Targeted Allele Detail

Summary

• Symbol: Atp13a2^tm1.2Wtd
• Name: ATPase type 13A2; targeted mutation 1.2, William T Dauer
• MGI ID: MGI:5642333
• Gene: Atp13a2 Location: Chr4:140714184-140734641 bp, + strand Genetic Position: Chr4, 73.29 cM
• Alliance: Atp13a2^tm1.2Wtd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221680
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked exons 2 and 3 were removed via cre-mediated recombination, resulting in an insertion of a premature stop codon in exon 4. RT-PCR analysis confirmed absence of RNA in the brain. (J:221680)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp13a2 Mutation: 61 strains or lines available

References

• Original: J:221680 Kett LR, et al., alpha-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015 Apr 8;35(14):5724-42
• All: 1 reference(s)