Tbp^tm1Xjl
Targeted Allele Detail

Summary

• Symbol: Tbp^tm1Xjl
• Name: TATA box binding protein; targeted mutation 1, Xiao-Jiang Li
• MGI ID: MGI:5644074
• Synonyms: TBP-105 glutamine^loxp
• Gene: Tbp Location: Chr17:15720150-15737689 bp, + strand Genetic Position: Chr17, 8.95 cM
• Alliance: Tbp^tm1Xjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221703
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with a floxed STOP, a neomycin resistance cassette and the corresponding human sequence for exon 2 with 105 CAG repeats. (J:221703)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbp Mutation: 10 strains or lines available

References

• Original: J:221703 Huang S, et al., Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain. 2011 Jul;134(Pt 7):1943-58
• All: 6 reference(s)