Col5a1^tm2.1Rjw
Targeted Allele Detail

Summary

• Symbol: Col5a1^tm2.1Rjw
• Name: collagen, type V, alpha 1; targeted mutation 2.1, Richard J Wenstrup
• MGI ID: MGI:5644153
• Synonyms: Col5a1^flox
• Gene: Col5a1 Location: Chr2:27776437-27929526 bp, + strand Genetic Position: Chr2, 19.38 cM, cytoband A2-B
• Alliance: Col5a1^tm2.1Rjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221469
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 3 and 4 floxed. (J:221469)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col5a1 Mutation: 66 strains or lines available

References

• Original: J:221469 Sun M, et al., Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model. J Cell Sci. 2011 Dec 1;124(Pt 23):4096-105
• All: 5 reference(s)