Bmi1^tm1Sgon
Targeted Allele Detail

Summary

• Symbol: Bmi1^tm1Sgon
• Name: Bmi1 polycomb ring finger oncogene; targeted mutation 1, Susana Gonzalez
• MGI ID: MGI:5644155
• Synonyms: Bmi1^fl
• Gene: Bmi1 Location: Chr2:18681953-18691440 bp, + strand Genetic Position: Chr2, 12.9 cM
• Alliance: Bmi1^tm1Sgon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221849
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:221849)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmi1 Mutation: 31 strains or lines available

References

• Original: J:221849 Arranz L, et al., Bmi1 is critical to prevent Ikaros-mediated lymphoid priming in hematopoietic stem cells. Cell Cycle. 2012 Jan 1;11(1):65-78
• All: 2 reference(s)