Map3k15^tm1Hijo
Targeted Allele Detail

Summary

• Symbol: Map3k15^tm1Hijo
• Name: mitogen-activated protein kinase kinase kinase 15; targeted mutation 1, Hidenori Ichijo
• MGI ID: MGI:5644160
• Synonyms: ASK3 KO
• Gene: Map3k15 Location: ChrX:158771429-158906347 bp, + strand Genetic Position: ChrX, 73.95 cM
• Alliance: Map3k15^tm1Hijo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221240
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the anterior part of exon 1. Western blot analysis confirmed the absence of protein expression in the kidney. (J:221240)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Map3k15 Mutation: 14 strains or lines available

References

• Original: J:221240 Naguro I, et al., ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. Nat Commun. 2012;3:1285
• All: 2 reference(s)