Baiap3^tm1Smwk
Targeted Allele Detail

Summary

• Symbol: Baiap3^tm1Smwk
• Name: BAI1-associated protein 3; targeted mutation 1, Sonja M Wojcik
• MGI ID: MGI:5644306
• Synonyms: Baiap3 KO
• Gene: Baiap3 Location: Chr17:25461633-25475255 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Baiap3^tm1Smwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first three coding exons. Western blot analysis revealed a truncated immunoreactive product in the brains of P0 homozygous mutant pups that decreased after P7 and was not detectable in adult mice. Immunofluorescence analysis confirmed the absence of protein expression in adult mutant brains. (J:221234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Baiap3 Mutation: 50 strains or lines available

References

• Original: J:221234 Wojcik SM, et al., Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. Mol Med. 2013;19:135-48
• All: 3 reference(s)