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Pcho6129S6/SvEvTac-Apoe-tm4Mae
QTL Variant Detail
Summary
QTL variant: Pcho6129S6/SvEvTac-Apoe-tm4Mae
Name: plasma cholesterol 6; 129S6/SvEvTac-Apoetm4Mae
MGI ID: MGI:5644669
QTL: Pcho6  Location: unknown  Genetic Position: Chr11, Syntenic
Variant
origin
Strain of Specimen:  129S6/SvEvTac-Apoetm4Mae
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:208464

Linkage analysis was performed on 137 female (129S6/SvEvTac-Apoetm4Mae x D2.129P2(B6)-Apoetm1Unc/J)F2 intercross mice using 170 SNP markers to identify QTL associated with total plasma cholesterol level.

QTL Pcho6 maps to 70-92 Mb (45-59 cM) on Chromosome 11 with a peak LOD score of 3.9 at 90 Mb (55 cM) in linkage with total plasma cholesterol level. 129S6/SvEvTac-Apoe alleles confer increased total plasma cholesterol level.

References
Original:  J:208464 Kayashima Y, et al., Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS One. 2014;9(2):e88274
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory